ANDROCUR 50 mg 20 pcs
Anti-Androgen and Hormonal Therapy
Description
Generic Name: Cyproterone Acetate
Brand Name: Androcur
Drug Class: Anti-androgen, Progestin
This is a prescription medicine, which requires a valid prescription!
Indications
- Prostate Cancer: Palliative treatment in advanced stages, often in combination with LHRH analogues.
- Sexual Deviations in Men: To reduce sexual drive in cases of severe hypersexuality.
- Hirsutism and Severe Acne in Women: Often used in women with androgen-dependent conditions when other treatments are ineffective (in lower doses and combined with estrogens).
- Androgenization Symptoms: Such as alopecia, seborrhea, or polycystic ovary syndrome (PCOS) – off-label in some cases.
Cyproterone acetate works by:
- Blocking androgen receptors, inhibiting the action of male sex hormones (testosterone and DHT).
- Suppressing gonadotropin secretion, leading to decreased production of testosterone.
- Exhibiting progestogenic effects, contributing to anti-gonadotropic activity and decreased libido.
- Form: Oral tablets
- Typical Dose:
- Men (Prostate cancer or sexual deviations): 50–100 mg once to twice daily
- Women: Usually 2 mg/day (in combination pills like Diane-35; not Androcur 50 mg — which is a high dose)
- Administration: Swallow whole with water after meals
- Duration: As directed by physician depending on indication (long-term for prostate cancer, short-term/intermittent for others)
- Common:
- Fatigue, depression
- Weight gain
- Hot flashes, sweating
- Breast tenderness or gynecomastia in men
- Reduced libido or erectile dysfunction
- Serious (rare):
- Liver toxicity (hepatitis, liver failure — monitor liver enzymes)
- Thromboembolism (risk increases when combined with estrogen)
- Benign or malignant liver tumors
- Osteoporosis with long-term use
- Anemia (rare but reported)
- Liver disease or history of hepatic tumors
- History of thromboembolic disorders
- Severe chronic depression
- Known hypersensitivity to cyproterone acetate
Information
Warnings and Precautions:
- Hepatic Risk: Liver function should be monitored before and during treatment.
- Thrombotic Risk: Use with caution in patients with cardiovascular risk factors or history of blood clots.
- Depression: Monitor for mood changes, especially in long-term users.
- Diabetes: May require insulin dose adjustments.
- Not recommended for children or adolescents.
Drug Interactions:
- CYP3A4 inhibitors/inducers: May alter cyproterone levels.
- Statins: Increased risk of liver injury and rhabdomyolysis.
- Other hormonal therapies: Increased side effects when used with estrogens or progestogens.
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