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Home » Medications » Metronidazole 400 mg Tbl 14 Stk

Metronidazole 400 mg Tbl 14 Stk

Antibiotic for anaerobic & protozoal infections

Description

Generic Name: Metronidazole
Brand Name: Flagyl, Metrosa, Rozex (topical), depending on region
Drug Class: itroimidazole antibiotic and antiprotozoal

This is a prescription medicine, which requires a valid prescription!

Indications

Metronidazole is used to treat various anaerobic bacterial and protozoal infections, including:

  • Bacterial vaginosis
  • Trichomoniasis (sexually transmitted protozoal infection)
  • Giardiasis and amoebiasis
  • Intra-abdominal infections (e.g., peritonitis, abscesses)
  • Pelvic inflammatory disease
  • Clostridioides difficile infection (alternative agent)
  • Dental infections and periodontal disease
  • Helicobacter pylori (as part of combination therapy)
Mechanism of Action
  • Disrupts DNA synthesis in susceptible organisms
  • Bactericidal and protozoacidal: causes strand breakage and cell death
  • Effective primarily against anaerobic bacteria and protozoa
Dosage and Administration
  • Form: Oral tablet, 400 mg
  • Typical Adult Dose:
    • 400–500 mg 2–3 times daily, depending on the indication
    • Duration: Usually 5–10 days
  • Take with food to reduce gastrointestinal upset
  • Avoid alcohol during treatment and for at least 48 hours after the last dose
Side Effects
  • Common:
    • Metallic taste
    • Nausea, vomiting
    • Abdominal cramps
    • Diarrhea or constipation
    • Headache
    • Dizziness
  • Less Common:
    • Skin rash or itching
    • Darkened urine (harmless)
  • Serious (Rare):
    • Seizures or peripheral neuropathy (especially with prolonged use)
    • Stevens-Johnson syndrome
    • Encephalopathy or cerebellar toxicity (very rare, usually reversible)
    • Severe allergic reactions (e.g., angioedema, anaphylaxis)
Contraindications
  • Hypersensitivity to metronidazole or other nitroimidazole derivatives
  • Use of alcohol or alcohol-containing products during and 48 hours after treatment
  • First trimester of pregnancy in patients with trichomoniasis (unless absolutely necessary)

Information

Warnings and Precautions

  • Avoid alcohol due to risk of disulfiram-like reaction (flushing, tachycardia, nausea)
  • Use with caution in patients with hepatic impairment or CNS disease
  • Long-term use may increase risk of peripheral neuropathy
  • May cause false-positive results in some lab tests (e.g., urine assays)
  • Pregnancy Category B (most infections); avoid in 1st trimester for trichomoniasis
  • Breastfeeding: Excreted in breast milk—consider interruption during short-term use

Drug Interactions

  • Alcohol: Causes disulfiram-like reaction
  • Warfarin: Potentiates anticoagulant effect—monitor INR closely
  • Disulfiram: Increased risk of psychotic reactions—avoid concurrent use
  • Lithium: Risk of lithium toxicity—monitor serum levels
  • Phenobarbital, phenytoin: May decrease metronidazole effectiveness

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