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Home » Medications » Alfuzosin (ER) – 10 mg, 30 stk.

Alfuzosin (ER) – 10 mg, 30 stk.

Alpha-blocker for BPH relief

Description

Generic Name: Alfuzosin hydrochloride (ER)
Brand Name: Uroxatral, Xatral XL, Alfural
Drug Class: Alpha-1 adrenergic receptor blocker


This is a prescription medicine, which requires a valid prescription!

Indications

  • Benign Prostatic Hyperplasia (BPH):
    • Relief of lower urinary tract symptoms (LUTS) due to BPH
    • Improves urine flow and reduces residual urine
  • Not indicated for hypertension
Mechanism of Action
  • Selective α1-adrenergic receptor antagonist
  • Relaxes smooth muscle in bladder neck and prostate
  • → Decreases urethral resistance and improves urinary flow
  • Extended-release (ER) formulation provides steady effect over 24 hours
Dosage and Administration
  • Dose: 10 mg once daily
  • Administration:
    • Take immediately after the same meal each day
    • Swallow whole; do not crush or chew (to preserve extended-release)
  • Onset of action: within hours; full benefit over several days to weeks
Side Effects
  • Common:
    • Dizziness
    • Headache
    • Fatigue
    • Upper respiratory tract infection
    • Abdominal pain
  • Less Common:
    • Orthostatic hypotension (especially at initiation)
    • Syncope
    • Retrograde ejaculation
  • Serious (rare):
    • QT prolongation (rare; caution in patients with risk factors)
    • Liver enzyme elevation
    • Angioedema (very rare)
Contraindications
  • Moderate to severe hepatic impairment
  • Known hypersensitivity to alfuzosin
  • Concurrent use with potent CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
  • History of postural hypotension

Information

Warnings and Precautions

  • Risk of orthostatic hypotension: caution when initiating or resuming after interruption
  • QT prolongation: use with caution in patients with congenital QT syndrome or those on QT-prolonging drugs
  • Floppy iris syndrome during cataract surgery: inform ophthalmologist if using
  • Not approved for use in women

Drug Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may ↑ plasma levels
  • Antihypertensives: additive hypotensive effects
  • Nitrates, PDE-5 inhibitors (e.g., sildenafil): caution due to BP lowering

Pregnancy and Lactation

  • Not indicated in women
  • Category B (animal data shows no harm, but not studied in humans)

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