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Home » Medications » Amiodarone – 200 mg, 100 stk.

Amiodarone – 200 mg, 100 stk.

Potent antiarrhythmic for serious arrhythmias

Description

Generic Name: Amiodarone
Brand Name: Cordarone, AmioHEXAL, Aratac
Drug Class: Class III antiarrhythmic agent


This is a prescription medicine, which requires a valid prescription!

Indications

  • Life-threatening ventricular arrhythmias (e.g., ventricular tachycardia, ventricular fibrillation)
  • Atrial fibrillation (especially when rhythm control is prioritized and other options are unsuitable)
  • Supraventricular tachycardia (SVT) in selected cases
  • Arrhythmia prophylaxis in certain high-risk cardiac conditions (off-label in some settings)
Mechanism of Action
  • Primarily blocks potassium channels → prolongs repolarization and action potential duration
  • Also has Class I (sodium channel), Class II (beta-blocker), and Class IV (calcium channel) effects
    • Slows heart rate and conduction through AV node
    • Increases refractory period
    • Suppresses ectopic pacemakers and reentry circuits
Dosage and Administration
  • Initial: 200–400 mg 2–3× daily for 1–2 weeks
  • Maintenance: 100–200 mg once daily (minimum effective dose)
  • Take consistently with regard to meals
  • Long half-life: up to 50 days
  • Requires close monitoring (ECG, labs, imaging)
Side Effects
  • Common:
    • Bradycardia
    • Hypotension (especially IV form)
    • Photosensitivity
    • Blue-gray skin discoloration (long-term use)
    • Nausea, metallic taste
  • Serious (can be life-threatening):
    • Pulmonary toxicity (interstitial pneumonitis, fibrosis)
    • Thyroid dysfunction (hypo- or hyperthyroidism)
    • Hepatotoxicity
    • Corneal deposits (visual halos, usually asymptomatic)
    • Neurotoxicity (tremor, ataxia, peripheral neuropathy)
    • QT prolongation → Torsades de Pointes (rare)
Contraindications
  • Sinus bradycardia or AV block (2nd or 3rd degree) without pacemaker
  • Severe sinus node dysfunction
  • Hypersensitivity to iodine or amiodarone
  • Pregnancy (especially in 1st trimester) and breastfeeding

Information

Warnings and Precautions

  • Pulmonary toxicity: Baseline and periodic chest X-rays or pulmonary function tests
  • Liver monitoring: LFTs baseline and during treatment
  • Thyroid monitoring: TSH and T4 before and during therapy
  • Eye exams if visual symptoms occur
  • Avoid excessive sunlight exposure; use sun protection
  • Monitor ECG and electrolytes regularly (especially potassium, magnesium)
  • Interferes with many common lab tests (due to iodine content)

Drug Interactions

  • Levels or effects of: Digoxin, Warfarin, Phenytoin, Cyclosporine, Statins (especially simvastatin)
  • Risk of bradycardia or QT prolongation with: Beta-blockers, calcium channel blockers, fluoroquinolones, macrolides
  • CYP3A4 and CYP2C9 substrate and inhibitor → extensive interaction potential
  • Grapefruit juice: may increase serum levels (avoid)

Pregnancy and Lactation

  • Pregnancy: Category D – risk to fetus; use only if life-threatening
  • Lactation: Contraindicated – excreted in breast milk and may harm infant

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