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Home » Medications » ANDROCUR 10 mg, 3 × 15 pcs (Cyproterone)

ANDROCUR 10 mg, 3 × 15 pcs

Anti-Androgen for Women | Hormonal Therapy

Description

Generic Name: Cyproterone Acetate
Brand Name: Androcur
Drug Class: Anti-androgen, Progestin


This is a prescription medicine, which requires a valid prescription!

Indications

  • Severe Acne and Seborrhea: Especially when resistant to other treatments.
  • Hirsutism: Excessive hair growth in women due to androgen sensitivity.
  • Polycystic Ovary Syndrome (PCOS): To manage symptoms related to elevated androgens.
  • Androgenic Alopecia: Hair loss caused by elevated or hypersensitive response to androgens.
  • Always used in combination with estrogens (e.g., ethinylestradiol) to prevent endometrial hyperplasia and enhance efficacy.
Mechanism of Action

Cyproterone acetate:

  • Blocks androgen receptors: Inhibits the effect of male hormones (testosterone, DHT) at the skin and hair follicle level.
  • Suppresses ovarian androgen production: Reduces hormone stimulation from the ovaries.
  • Has progestogenic activity: Regulates menstrual cycles and prevents ovulation.
Dosage and Administration
  • Form: Oral tablets
  • Strength: 10 mg
  • Typical Dose for Women:
    • 1 tablet (10 mg) once daily from day 1 to day 15 of the menstrual cycle, usually combined with an estrogen (e.g., ethinylestradiol or in oral contraceptive form).
  • Administration: Take with water at the same time each day.
  • Package: 3 × 15 tablets (45 total) — typically a 3-cycle treatment pack
Side Effects
  • Common:
    • Breast tenderness
    • Headache
    • Nausea
    • Menstrual irregularities
    • Mood swings
  • Serious (rare):
    • Venous thromboembolism (VTE) — especially when combined with estrogen
    • Liver dysfunction
    • Depression or mood changes
    • Weight changes
Contraindications
  • History of or active thromboembolic disorders
  • Severe liver disease or hepatic tumors
  • Meningioma (present or past)
  • Undiagnosed vaginal bleeding
  • Pregnancy or breastfeeding

Information

Warnings and Precautions:

  • VTE Risk: Increased when combined with estrogens — avoid in women with clotting history or risk factors.
  • Liver Monitoring: Use with caution in patients with hepatic impairment.
  • Meningioma: Long-term use linked to increased risk — treatment should be reassessed regularly.
  • Pregnancy: Contraindicated — ensure effective contraception during use.
  • Lactation: Not recommended while breastfeeding.

Drug Interactions:

  • CYP3A4 inhibitors/inducers: May alter blood levels of cyproterone.
  • Other hormonal treatments: Monitor cumulative effects and side effects.
  • Anticoagulants: May alter bleeding risk — monitor INR if on warfarin.

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