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Home » Medications » BINABIC 50 mg Tbl Flm, 28 Stk

BINABIC 50 mg Tbl Flm, 28 Stk

Prostate Cancer Treatment

Description

Generic Name: Bicalutamide
Brand Name: Binabic
Drug Class: Non-steroidal anti-androgen (NSAA)


This is a prescription medicine, which requires a valid prescription!

Indications

Prostate Cancer:

  • Used in combination with luteinizing hormone-releasing hormone (LHRH) analogues for the treatment of advanced prostate cancer.
  • Also used as monotherapy in some localized or locally advanced prostate cancers.
Mechanism of Action

Bicalutamide works by:

  • Slowing or stopping the progression of the disease.
  • Binding to androgen receptors on prostate cancer cells.
  • Blocking the action of testosterone and dihydrotestosterone, which fuel the growth of prostate cancer.
Dosage and Administration
  • Form: Film-coated oral tablets
  • Dose: 50 mg once daily
  • Administration:
    • Can be taken with or without food.
    • Should be started at the same time as LHRH analog treatment in combination therapy.
  • Duration: As prescribed by an oncologist, often long-term.
Side Effects
  • Common:
    • Breast tenderness or enlargement (gynecomastia)
    • Hot flashes
    • Nausea, constipation
    • Fatigue
    • Increased liver enzymes
  • Serious (rare):
    • Liver toxicity (hepatitis, jaundice)
    • Interstitial lung disease (rare respiratory side effects)
    • Cardiac disorders in patients with pre-existing heart disease
    • Depression or mood changes
Contraindications
  • Women and children (Bicalutamide is only indicated for male patients)
  • Severe hepatic impairment
  • Hypersensitivity to bicalutamide or any excipients
  • Concurrent use with terfenadine, astemizole, or cisapride (due to risk of QT prolongation)

Information

Warnings and Precautions:

  • Liver Function: Monitor liver enzymes regularly; discontinue if severe abnormalities occur.
  • Diabetes: May affect glucose tolerance when used with LHRH analogues.
  • Heart Disease: Caution in patients with cardiac conditions.
  • Fertility: Can impair male fertility during and after treatment.
  • Pregnancy and Lactation: Not for use in women.

Drug Interactions:

  • Warfarin: May enhance anticoagulant effects — monitor INR closely.
  • CYP3A4 Inhibitors/Inducers: May affect plasma levels of bicalutamide.
  • Cyclosporine, Tacrolimus: May increase levels and toxicity.

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