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Home » Medications » Bisoprolol 5 mg Tbl 50 Stk

Bisoprolol 5 mg Tbl 50 Stk

Cardioselective beta-blocker

Description

Generic Name: Bisoprolol fumarate
Brand Name: Concor, Zebeta, Emcor, various generics
Drug Class: β1-selective beta-blocker (Cardioselective beta-adrenergic antagonist)


This is a prescription medicine, which requires a valid prescription!

Indications

  • Hypertension (high blood pressure)
  • Chronic stable angina pectoris
  • Chronic heart failure (in combination with ACE inhibitors and diuretics)
  • Rate control in atrial fibrillation (off-label)
Mechanism of Action

Bisoprolol selectively blocks β1-adrenergic receptors (mainly in the heart), which:

  • Reduces heart rate and myocardial contractility
  • Decreases cardiac output and blood pressure
  • Lowers oxygen demand in the myocardium
  • Helps improve symptoms and survival in chronic heart failure
Dosage and Administration
  • Hypertension/Angina Starting Dose: 5 mg once daily
  • Maintenance Dose: 5–10 mg once daily (max 20 mg/day)
  • Heart Failure Starting Dose: 1.25 mg once daily (titrated gradually to 10 mg max)
  • Take with or without food, at the same time daily
  • Dose adjustment may be needed in renal or hepatic impairment
Side Effects
  • Common:
    • Bradycardia (slow heart rate)
    • Fatigue, dizziness
    • Hypotension
    • Cold extremities
    • Headache
  • Less Common:
    • Sleep disturbances (e.g. insomnia, vivid dreams)
    • Depression
    • Gastrointestinal issues (nausea, diarrhea)
  • Serious (rare):
    • Worsening of heart failure (during initiation or titration)
    • Bronchospasm (especially in asthmatic patients)
    • AV block or severe bradycardia
    • Hypoglycemia unawareness (in diabetics)
Contraindications
  • Acute heart failure or decompensated heart failure
  • Cardiogenic shock
  • Severe bradycardia (<60 bpm), second- or third-degree AV block (without pacemaker)
  • Sick sinus syndrome
  • Severe asthma or chronic obstructive pulmonary disease (relative)
  • Hypersensitivity to bisoprolol or other beta-blockers

Information

Warnings and Precautions:

  • Do not stop abruptly—may cause rebound tachycardia or hypertension
  • Use caution in diabetes (can mask hypoglycemia symptoms)
  • Caution in patients with COPD, peripheral artery disease, or thyroid disorders
  • Monitor heart rate and blood pressure regularly
  • Use carefully in elderly or those with impaired renal/hepatic function

Drug Interactions:

  • Other antihypertensives or antiarrhythmics (e.g. verapamil, diltiazem): Risk of bradycardia or AV block
  • Insulin/oral antidiabetics: May mask signs of hypoglycemia
  • NSAIDs: May reduce antihypertensive effect
  • Clonidine: Risk of severe rebound hypertension if stopped suddenly
  • Anesthetics: Increased risk of bradycardia and hypotension during surgery

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