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Diclofenac- 50 mg , 100 stk.

Anti-inflammatory pain reliever (NSAID)

Description

Generic Name: Diclofenac
Brand Name: Diclac®, Dicloflex®, Voltaren®
Drug Class: NSAID – Nonsteroidal Anti-Inflammatory Drug


This is a prescription medicine, which requires a valid prescription!

Indications

  • Rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis
  • Acute musculoskeletal pain or injury
  • Back pain, joint pain, or dental pain
  • Dysmenorrhea (menstrual cramps)
  • Gout (acute attacks)
  • Postoperative or post-traumatic inflammation
Mechanism of Action
  • Inhibits cyclooxygenase enzymes (COX-1 and COX-2)
  • Reduces synthesis of prostaglandins
  • Provides anti-inflammatory, analgesic, and antipyretic effects
Dosage and Administration
  • Form: Oral tablet
  • Typical Adult Dose: 50 mg 2–3 times daily (max 150 mg/day)
  • Use the lowest effective dose for the shortest duration
  • Take with food or milk to minimize gastrointestinal irritation
Side Effects
  • Common:
    • Nausea, indigestion
    • Abdominal pain
    • Headache
    • Dizziness
  • Serious (rare):
    • Gastrointestinal ulcer or bleeding
    • Elevated liver enzymes or hepatotoxicity
    • Cardiovascular events (e.g., heart attack, stroke)
    • Kidney impairment
    • Hypersensitivity reactions (e.g., rash, asthma exacerbation)
Contraindications
  • Known hypersensitivity to diclofenac or other NSAIDs
  • History of peptic ulcer or GI bleeding
  • Active gastrointestinal ulceration or bleeding
  • Severe heart failure
  • Severe liver or renal dysfunction
  • History of asthma, urticaria, or allergic-type reaction after NSAID use
  • Third trimester of pregnancy

Information

Warnings and Precautions

  • Increased risk of serious CV thrombotic events (especially with prolonged use)
  • Monitor for signs of GI bleeding, liver or kidney dysfunction
  • Use with caution in elderly patients and those with comorbid conditions
  • Avoid combining with other NSAIDs or corticosteroids

Drug Interactions

  • Anticoagulants (e.g., warfarin) → increased bleeding risk
  • ACE inhibitors/ARBs → may reduce renal function
  • Diuretics → may reduce efficacy
  • Lithium or methotrexate → may increase toxicity
  • SSRIs → increased risk of GI bleeding

Pregnancy and Lactation

  • Pregnancy: Avoid in 3rd trimester; may cause premature closure of ductus arteriosus
  • Lactation: Present in breast milk in small amounts; use with caution

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Terms & Conditions

Direct Enquiries
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