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Home » Medications » Enalapril/Hydrochlorothiazide-  20 mg / 12.5 mg, 30 stk.

Enalapril/Hydrochlorothiazide-  20 mg / 12.5 mg, 30 stk.

Dual-action antihypertensive:

Description

Generic Name: Enalapril maleate / Hydrochlorothiazide
Brand Name: Co-Renitec®, Enalapril comp.®
Drug Class:

  • Enalapril – ACE inhibitor (Angiotensin-Converting Enzyme inhibitor)
  • Hydrochlorothiazide – Thiazide diuretic


This is a prescription medicine, which requires a valid prescription!

Indications

  • Hypertension (high blood pressure), when monotherapy is insufficient
  • May reduce the risk of cardiovascular events associated with hypertension
Mechanism of Action
  • Enalapril:
    • Inhibits ACE → reduces angiotensin II → vasodilation
    • Lowers aldosterone → decreases sodium and water retention
  • Hydrochlorothiazide:
    • Inhibits sodium/chloride reabsorption in the distal renal tubule → diuretic effect
  • Combined effect enhances BP control via complementary mechanisms
Dosage and Administration
  • Form: Oral tablet
  • Typical Adult Dose: 1 tablet (20/12.5 mg) once daily
  • Adjust dosage based on clinical response and blood pressure levels
  • Take with or without food, ideally at the same time daily
  • Not suitable for initial therapy in patients with volume depletion or renal impairment
Side Effects
  • Common:
    • Dizziness, headache
    • Fatigue
    • Increased urination
    • Cough (from ACE inhibitor)
    • Electrolyte imbalance (e.g., low potassium or sodium)
  • Serious (rare):
    • Angioedema
    • Hypotension
    • Renal dysfunction
    • Hyperkalemia
    • Hepatic impairment
    • Severe skin reactions (e.g., Stevens-Johnson syndrome)
Contraindications
  • History of angioedema related to ACE inhibitor use
  • Anuria or severe renal impairment
  • Hypersensitivity to sulfonamide-derived drugs (HCTZ)
  • Pregnancy (especially in 2nd and 3rd trimester)
  • Concomitant use with aliskiren in patients with diabetes or renal impairment

Information

Warnings and Precautions

  • Monitor electrolytes (especially potassium, sodium) and renal function regularly
  • May increase serum uric acid (risk of gout)
  • Use caution in patients with diabetes, liver disease, or autoimmune conditions
  • Avoid use in pregnancy and switch to safer alternatives if planning pregnancy

Drug Interactions

  • Potassium supplements or potassium-sparing diuretics → ↑ risk of hyperkalemia
  • NSAIDs → may reduce antihypertensive effect and worsen renal function
  • Lithium → ↑ lithium levels and toxicity risk
  • Alcohol or other antihypertensives → additive hypotensive effects

Pregnancy and Lactation

  • Pregnancy: Contraindicated (ACE inhibitors can cause fetal injury/death)
  • Lactation: Enalapril may be present in breast milk; avoid if possible

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Terms & Conditions

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