Gynokadin 2 mg Tablets 100 Stk (Estradiol)
Hormone Replacement Therapy (HRT)
Description
Generic Name: Estradiol
Brand Name: Gynokadin
Drug Class: Estrogen, natural estrogen hormone replacement
This is a prescription medicine, which requires a valid prescription!
Indications
- Postmenopausal Hormone Replacement Therapy (HRT):
- Relief of moderate to severe menopausal symptoms: hot flashes, night sweats, vaginal dryness, mood swings.
- Prevention of osteoporosis in postmenopausal women at risk of fractures and intolerant to or contraindicated for other osteoporosis treatments.
- Estrogen Deficiency:
- Management of hypoestrogenism due to hypogonadism, castration, or primary ovarian failure.
- Management of hypoestrogenism due to hypogonadism, castration, or primary ovarian failure.
Gynokadin contains micronized 17β-estradiol, which is chemically identical to the endogenous estrogen produced by the ovaries. It works by:
- Binding to estrogen receptors in tissues like bone, brain, and the urogenital tract.
- Alleviating vasomotor symptoms (hot flashes, sweating).
- Restoring vaginal and urinary tract health.
- Inhibiting bone resorption, helping maintain bone density.
- Form: Oral tablets, 2 mg estradiol
- Starting Dose: 1–2 mg daily (depending on symptom severity), adjusted individually.
- Maintenance Dose: Lowest effective dose for shortest duration.
- Cycle Options:
- Women with a uterus: Combine with a progestogen for at least 12–14 days per 28-day cycle to protect against endometrial hyperplasia.
- Women without a uterus: Estradiol monotherapy may be used continuously.
- Women with a uterus: Combine with a progestogen for at least 12–14 days per 28-day cycle to protect against endometrial hyperplasia.
- Administration: Take one tablet daily at the same time with or without food.
- Common:
- Nausea, bloating
- Breast tenderness or swelling
- Headache
- Irregular vaginal bleeding or spotting
- Mood changes, irritability
- Serious (rare):
- Stroke or myocardial infarction
- Venous thromboembolism (VTE): DVT, PE
- Endometrial hyperplasia or carcinoma (when unopposed by progestogen)
- Breast cancer (risk increases with duration of use)
- Gallbladder disease
- Liver dysfunction
- Stroke or myocardial infarction
- Known or suspected estrogen-dependent malignancies (e.g., breast or endometrial cancer)
- Active or history of venous thromboembolism (deep vein thrombosis, pulmonary embolism)
- Undiagnosed abnormal vaginal bleeding
Information
Warnings and Precautions:
- Endometrial Safety: Use a progestogen in women with an intact uterus to prevent endometrial cancer.
- Cardiovascular Risk: Increased risk of stroke, heart attack, and VTE in postmenopausal women, especially over 60.
- Breast Cancer: Use lowest effective dose; regular screening recommended.
- Liver Function: Contraindicated in women with active liver disease.
- Undiagnosed Vaginal Bleeding: Must be evaluated before starting treatment.
- Pregnancy and Lactation: Contraindicated.
Drug Interactions:
- CYP3A4 Inducers (e.g., carbamazepine, phenytoin, rifampicin): May reduce efficacy of estradiol.
- Thyroid Hormone Replacement: Estrogens may increase thyroxine-binding globulin, requiring dose adjustment of levothyroxine.
- Anticoagulants (e.g., warfarin): Monitor INR if co-administered.
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pharmacy@doctorworld.eu
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