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Home » Medications » LISINOPRIL 10 mg Tablets (30 Stk)

ESTRIFAM 2 mg Film-coated Tablets

Antihypertensive Agent (ACE Inhibitor)

Description

Generic Name:  Lisinopril
Brand Name:  Various generics
Drug Class: Angiotensin-Converting Enzyme (ACE) Inhibitor


This is a prescription medicine, which requires a valid prescription!

Indications

Hypertension:

  • Treatment of high blood pressure to reduce the risk of cardiovascular events such as stroke and myocardial infarction.

Heart Failure:

  • To improve survival and reduce complications after a heart attack.

Post-Myocardial Infarction:

  • To improve survival and reduce complications after a heart attack.

Diabetic Nephropathy:

  • To reduce progression of kidney disease in hypertensive patients with type 1 diabetes and proteinuria.


Mechanism of Action
  • Lisinopril inhibits the angiotensin-converting enzyme (ACE), preventing conversion of angiotensin I to angiotensin II.
  • This leads to vasodilation, decreased aldosterone secretion, and reduced blood pressure.
  • The reduction in angiotensin II decreases vasoconstriction and sodium and water retention, lowering blood volume and pressure.
Dosage and Administration
  • Form: Oral tablets, 10 mg
  • Typical Starting Dose:
    • Hypertension: 10 mg once daily; may adjust based on response.
    • Heart failure or post-MI: dosing individualized, often starting lower.
  • Maintenance Dose:
    • Usually 20–40 mg once daily, up to 80 mg daily in divided doses.
  • Administration:
    • Taken orally, with or without food, at the same time each day.
Side Effects
  • Common (usually mild and gastrointestinal):
    • Cough (dry, persistent)
    • Dizziness or hypotension (especially after first dose)
    • Headache
    • Fatigue
    • Hyperkalemia (high potassium)
    • Elevated serum creatinine
  • Serious (rare):
    • Angioedema (potentially life-threatening swelling of face, lips, tongue, or airway)
    • Kidney dysfunction or failure
    • Severe hypotension
    • Neutropenia or agranulocytosis (rare)
Contraindications
  • History of angioedema related to previous ACE inhibitor therapy
  • Bilateral renal artery stenosis or severe renal impairment
  • Hypersensitivity to lisinopril or any ACE inhibitor
  • Pregnancy: especially in the 2nd and 3rd trimesters (can cause fetal injury or death)
  • Use with aliskiren in patients with diabetes or renal impairment (contraindicated)

Information

Warnings and Precautions:

  • Monitor blood pressure, kidney function, and serum potassium regularly.
  • Caution in patients with impaired renal function or volume depletion.
  • Avoid NSAIDs where possible; can reduce antihypertensive effect and worsen renal function.
  • Inform patients to report signs of angioedema immediately.
  • Not recommended during pregnancy or breastfeeding.

Drug Interactions:

  • Potassium supplements or potassium-sparing diuretics increase risk of hyperkalemia.
  • NSAIDs may reduce antihypertensive effect and impair renal function.
  • Lithium toxicity risk increases when combined with ACE inhibitors.

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