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Home » Medications » LONOLOX 2.5 mg Tablets (Minoxidil)

LONOLOX 2.5 mg Tablets (Minoxidil)

Antihypertensive Agent

Description

Generic Name: Minoxidil
Brand Name: Lonolox
Drug Class: Vasodilator (potent arterial vasodilator)


This is a prescription medicine, which requires a valid prescription!

Indications

Severe Hypertension:

  • Used in cases of severe hypertension unresponsive to standard therapy (resistant hypertension).
  • Typically reserved for patients who have not responded adequately to other antihypertensive medications.
Mechanism of Action
  • Minoxidil acts by directly relaxing vascular smooth muscle in arterial walls, causing vasodilation and reduced peripheral vascular resistance.
  • This leads to a decrease in blood pressure.
  • Due to its potency, it may cause reflex tachycardia and sodium retention.
Dosage and Administration
  • Form: Oral tablets, 2.5 mg
  • Starting Dose:
    • Usually 5 mg daily in divided doses, adjusted based on patient response (initial dose may be lower depending on clinical condition).
  • Maintenance Dose:
    • Typically ranges from 10 to 40 mg daily, divided into 1 to 2 doses.
  • Administration:
    • Take with food to improve absorption and reduce gastrointestinal discomfort.
    • Dosing must be individualized carefully due to potent effects.
  • Adjunct Therapy:
    • Usually combined with a beta-blocker to control reflex tachycardia and a diuretic to counteract fluid retention.
Side Effects
  • Common (usually mild and gastrointestinal):
    • Hypertrichosis (excessive hair growth)
    • Tachycardia
    • Fluid retention and edema
    • Headache
    • Palpitations
  • Serious (rare):
    • Pericardial effusion (fluid around the heart)
    • Congestive heart failure exacerbation
    • Severe hypotension
    • Allergic reactions
Contraindications
  • Known hypersensitivity to minoxidil or any formulation components.
  • Pheochromocytoma: May worsen hypertension due to catecholamine release.
  • Severe heart disease: Patients with ischemic heart disease or heart failure should use with caution; risk of exacerbating symptoms.
  • Tachyarrhythmias: Caution or avoidance in patients with uncontrolled arrhythmias due to risk of reflex tachycardia.
  • Pregnancy and Lactation: Use only if clearly needed and under medical supervision.

Information

Warnings and Precautions:

  • Monitor for signs of fluid overload and cardiac status regularly.
  • Use alongside beta-blockers and diuretics to minimize side effects.
  • Regular blood pressure monitoring essential to avoid hypotension.

Drug Interactions:

  • Combination with other antihypertensives can enhance blood pressure lowering effect.
  • Diuretics reduce sodium retention caused by minoxidil.
  • Beta-blockers reduce reflex tachycardia.

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Terms & Conditions

Direct Enquiries
For any inquiries, please feel free to contact us directly via email at the link below.
pharmacy@doctorworld.eu

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