Meropenem- 1 g vial (IV), 1 stk.
Broad-spectrum IV carbapenem antibiotic
Description
Generic Name: Meropenem
Brand Name: Meronem
Drug Class: Carbapenem antibiotic (β-lactam family)
This is a prescription medicine, which requires a valid prescription!
Indications
- Broad-spectrum treatment of serious bacterial infections including:
- Complicated intra-abdominal infections
- Bacterial meningitis
- Complicated skin and soft tissue infections
- Hospital-acquired pneumonia (including ventilator-associated pneumonia)
- Sepsis, febrile neutropenia, and urinary tract infections
- Active against many Gram-positive, Gram-negative, and anaerobic bacteria
Meropenem:
- Inhibits bacterial cell wall synthesis by binding to multiple penicillin-binding proteins (PBPs)
- Resistant to most β-lactamases, including extended-spectrum β-lactamases (ESBLs)
- Results in bacterial lysis and death
- Rapidly bactericidal
- Form: Intravenous (IV) vial – 1 g
- Typical Adult Dose:
- 500 mg to 1 g every 8 hours IV
- Higher doses (2 g every 8 hrs) may be used for severe infections (e.g., meningitis or multidrug-resistant organisms)
- Infusion over 15–30 minutes
- Dose adjustment required in renal impairment
- Common:
- Nausea, vomiting, diarrhea
- Headache
- Rash, injection site reactions
- Serious:
- Seizures (especially at high doses or in renal impairment)
- Clostridioides difficile-associated diarrhea
- Hypersensitivity reactions (including anaphylaxis)
- Hypersensitivity to meropenem or other carbapenems
- Severe hypersensitivity to other β-lactam antibiotics (cross-reactivity possible)
Information
Warnings and Precautions
- Central nervous system disorders: increased seizure risk in patients with CNS pathology or renal dysfunction
- Hypersensitivity: use caution in patients with a history of penicillin or other β-lactam allergies
- Monitor renal function during therapy
Drug Interactions
- Valproic acid: meropenem significantly reduces valproic acid levels — avoid combination
- Probenecid: may increase plasma levels of meropenem
Pregnancy & Lactation
- Pregnancy: Category B — no known teratogenic effects in animals; use if clearly needed
- Lactation: Present in small amounts in breast milk; caution advised
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