Naproxen 250 mg Tbl 30 Stk
Anti-inflammatory pain reliever
Description
Generic Name: Naproxen
Brand Name: Aleve, Naprosyn, Proxen, Apranax
Drug Class: NSAID (Nonsteroidal Anti-inflammatory Drug)
This is a prescription medicine, which requires a valid prescription!
Indications
- Musculoskeletal pain (e.g. back pain, sprains, strains)
- Inflammatory conditions: Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis
- Dysmenorrhea (menstrual pain)
- Acute gout attacks
- Headache or migraine
- Mild to moderate general pain
Naproxen works by:
- Inhibiting cyclooxygenase (COX-1 and COX-2) enzymes
- Reducing prostaglandin synthesis → alleviates inflammation, pain, and fever
- Dosage and Administration
- Form: Oral tablet
- Strength: 250 mg
- Adults:
- Initial dose: 250–500 mg twice daily
- Maintenance: 250 mg every 6–8 hours as needed
- Max daily dose: 1000–1250 mg (short-term); lower for chronic use
- Administration: Take with food or milk to reduce stomach irritation
Common:
- Nausea, indigestion
- Heartburn, abdominal pain
- Headache, dizziness
Serious (rare):
- Gastrointestinal ulcers or bleeding
- Cardiovascular events (heart attack, stroke – with long-term use)
- Kidney dysfunction
- Allergic reactions (rash, anaphylaxis, asthma exacerbation)
- Active gastric or intestinal ulcer
- GI bleeding or perforation history
- Severe renal or hepatic impairment
- NSAID or aspirin allergy (especially with bronchospasm)
- Pregnancy (3rd trimester)
- History of cardiovascular disease (use with caution)
Information
Warnings and Precautions
- GI risk: Use lowest effective dose, consider gastroprotection (e.g. PPI) in high-risk patients
- Cardiovascular risk: Avoid prolonged high-dose use in patients with heart disease
- Kidney function: Monitor in elderly or volume-depleted individuals
- Pregnancy: Avoid in late pregnancy; may affect fetal circulation
- Breastfeeding: Small amounts pass into breast milk; use with caution
- Avoid combining with other NSAIDs or aspirin without medical advice
Drug Interactions
- Anticoagulants (e.g. warfarin): ↑ bleeding risk
- Other NSAIDs or corticosteroids: ↑ GI toxicity
- ACE inhibitors/diuretics: ↓ efficacy, ↑ kidney risk
- Lithium: ↑ lithium levels
- Methotrexate: ↑ toxicity risk
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