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Home » Medications » Omeprazol 20 mg Kaps ent 28 Stk

Omeprazol 20 mg Kaps ent 28 Stk

Reduces stomach acid

Description

Generic Name: Amlodipine Besylate
Brand Name: Losec, Prilosec, Antra, Omep (varies by region)
Drug Class: Proton Pump Inhibitor (PPI)


This is a prescription medicine, which requires a valid prescription!

Indications

  • Gastroesophageal Reflux Disease (GERD): Treatment of acid reflux and erosive esophagitis
  • Peptic Ulcer Disease: Healing of gastric and duodenal ulcers
  • Helicobacter pylori Eradication: As part of triple therapy with antibiotics
  • Zollinger–Ellison Syndrome: Management of excessive gastric acid secretion
  • NSAID-Associated Ulcer Prevention: For at-risk patients requiring NSAIDs
Mechanism of Action

Omeprazole suppresses gastric acid secretion by:

  • Irreversibly inhibiting the H⁺/K⁺ ATPase enzyme (proton pump) in parietal cells
  • Blocking the final step of acid production
  • Reducing both basal and stimulated acid secretion
Dosage and Administration
  • Form: Enteric-coated capsule (delayed-release)
  • Strength: 20 mg
  • Usual Adult Dosage:
    • GERD/Ulcers: 20 mg once daily for 4–8 weeks
    • H. pylori: 20 mg twice daily for 7–14 days (with antibiotics)
    • Zollinger–Ellison Syndrome: Individualized; start at 60 mg/day and adjust as needed
  • Administration: Swallow whole before a meal; do not crush or chew
Side Effects
  • Common:
    • Headache
    • Abdominal pain
    • Nausea
    • Flatulence
    • Diarrhea or constipation
  • Serious (rare):
    • Vitamin B12 deficiency (with long-term use)
    • Hypomagnesemia
    • Clostridioides difficile–associated diarrhea
    • Bone fractures (hip, spine, wrist)
    • Kidney issues (acute interstitial nephritis)
    • Lupus erythematosus (rare)
Contraindications
  • Hypersensitivity to omeprazole, other PPIs, or capsule ingredients
  • Concomitant use with rilpivirine (an HIV medication)

Information

Warnings and Precautions

  • Long-Term Use: May increase risk of fractures, low magnesium, and vitamin B12 deficiency
  • Gastric Cancer: Symptom relief does not exclude malignancy; evaluate if persistent symptoms
  • Hepatic Impairment: Use cautiously; omeprazole is metabolized in the liver
  • Pregnancy: Generally considered safe (category B); consult a healthcare provider
  • Breastfeeding: Low levels in breast milk; generally considered acceptable

Drug Interactions

  • Reduces absorption of drugs requiring acid (e.g., ketoconazole, atazanavir)
  • May increase levels of: diazepam, warfarin, phenytoin
  • May reduce effectiveness of: clopidogrel (antiplatelet agent)
  • Delayed absorption if taken with antacids or sucralfate; stagger dosing

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