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Home » Medications » Questran 4g (cholestyramine resin)

Questran 4g (cholestyramine resin)

Cholesterol-Lowering & Bile Acid Sequestrant

Description

Generic Name: Cholestyramine resin
Brand Name: Questran
Drug Class: Bile acid sequestrant
Manufacturer: EMRA-MED Arzneimittel GmbH
Country of Origin: Germany
This is a prescription medicine, which requires a valid prescription!

Indications

  • Questran is used for:
    • Treatment and prevention of atherosclerosis and its complications (eg, myocardial infarction)
    • Hypercholesterolemia: Reduces elevated blood cholesterol levels
    • Partial obstruction of the bile ducts (to relieve itching)
    • Adjunct therapy in bile duct-related liver conditions and dietary cholesterol management
Mechanism of Action
  • Cholestyramine resin binds bile acids in the intestine, forming insoluble complexes that are excreted in feces. This:
    • Prevents reabsorption of bile acids
    • Stimulates liver conversion of cholesterol to bile acids
    • Lowers serum cholesterol
    • Aids in bile elimination in obstructive conditions
Dosage and Administration
  • Form: Powder (oral suspension)
  • Strength: 4 g Cholestyramine resin per sachet
  • Dosage: As prescribed by a physician; usually taken 1–2 times daily
  • Administration: Dissolve in water or non-carbonated beverage and drink immediately after mixing
Side Effects
  • Common:
    • Flatulence
    • Constipation or diarrhea
    • Heartburn
    • Nausea or vomiting
    • Abdominal discomfort
  • Serious (rare):
    • Steatorrhea
    • Pancreatitis exacerbation
    • GI bleeding (especially in ulcer patients)
    • Skin rashes or irritation
Contraindications
  • Do not use Questran if you have:
    • Complete bile duct obstruction
    • Phenylketonuria (PKU)
    • Known hypersensitivity to cholestyramine or formulation ingredients
    • Pregnancy or lactation (unless specifically advised by a healthcare provider)

Information

Warnings and Precautions:

  • Vitamin Deficiencies: Long-term use may reduce absorption of fat-soluble vitamins (A, D, E, K); supplementation may be required.
  • Gastrointestinal Disorders: Use with caution in patients with chronic constipation, hemorrhoids, or a history of gastrointestinal disease.
  • Phenylketonuria (PKU): Some formulations may contain phenylalanine.
  • Fluid Intake: Adequate hydration is important to prevent constipation and fecal impaction.
  • Pediatric Use: Safety and efficacy in children have not been established without medical supervision.

Drug Interactions:

  • Cholestyramine may interfere with the absorption of:
    • Thyroid hormones (eg, levothyroxine)
    • Oral anticoagulants (eg, warfarin)
    • Diuretics (eg, furosemide)
    • Antibiotics (eg, tetracycline, penicillin G)
    • Fat-soluble vitamins (A, D, E, K)
    • Other medications: Administer other oral drugs at least 1 hour before or 4–6 hours after taking Questran to avoid interaction.

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